Cascade
Roman Brunecky (UCD)

Protein Data Bank, Pymol, Illustrator
This work illustrates the MAP kinase cascade. This is a critical signal amplifying cascade used in many signaling systems in the cell. The extracellular-signal regulated kinase/mitogen-activated protein kinase (ERK/MAPK) cascade in is critical in learning and memory formation. The ERK/MAP kinase cascade is also a critical player in synaptic and neuronal plasticity. Also illustrated are structural cartoon representations of the kinases involved in the cascade.